220384-25-8

ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1].

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[1] K Kalman, et al. ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide. J Biol Chem. 1998 Dec 4;273(49):32697-707. DOI:10.1074/jbc.273.49.32697