219715-34-1

2-Methoxy-4-(trifluoromethyl)pyridine

In a dry reaction flask, 2-chloro-4-trifluoromethylpyridine (45.5 g, 0.251 mol) and a 30% mass fraction of sodium methanol solution (135.5 g, 0.753 mol) were added. The mixture was stirred well and then heated to 65 °C and maintained at that temperature for the reaction. The progress of the reaction was monitored by gas chromatography (GC) until complete conversion of the feedstock. After completion of the reaction, the reaction mixture was cooled to room temperature and filtered to remove insoluble material. Subsequently, methanol was recovered by distillation under reduced pressure. Water was added to the residue and extracted with dichloromethane to separate the organic and aqueous phases. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the light yellow liquid product 2-methoxy-4-trifluoromethylpyridine (40.9 g, 92.1% yield).

[1] Patent: CN108558744, 2018, A. Location in patent: Paragraph 0052-0055
[2] Patent: EP1559320, 2005, A1. Location in patent: Page/Page column 9