217480-25-6

L-796,778 is bioactive chemical.

L-796778 is an agonist of the hsst3 receptor. In CHO-K1 cells expressing the hsst3 receptor, L-796778 is a partial agonist that inhibits forskolin (HY-15371)-stimulated cAMP production with an IC50 value of 18 nM[1].

ChEBI: L-796,778 is a methyl ester resulting from the formal condensation of the carboxy group of N-{[(2S)-1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-D-norleucyl-L-lysine with methanol. It is a partial agonist of somatostatin subtype receptor 3 (Ki = 24 nM) that exhibits anticonvulsant effects. It has a role as a somatostatin receptor agonist. It is a methyl ester, a C-nitro compound, a member of ureas, a L-phenylalanine derivative, a L-lysine derivative, a secondary carboxamide, a member of benzenes and an oligopeptide.

SSTR3

[1] Pfeiffer M,et al. Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A). J Biol Chem. 2001 Apr 27;276(17):14027-36. DOI:10.1074/jbc.M006084200