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217082-58-1

Supplier Related Products Identification Chemical Properties Safety Data Hazard Information

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Identification

Name
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
CAS
217082-58-1
Synonyms
APELIN-13
QRPRLSHKGPMPF
PREPRO-65-77-APELIN
APELIN-13 (HUMAN, BOVINE)
apelin-13 trifluoroacetate salt
APELIN-13 (HUMAN, BOVINE, MOUSE, RAT)
Apelin-13 trifluoroacetate salt >=95%
Apelin-13, human, bovine, mouse, rat (2)
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE USP/EP/BP
Apelin-13 (human, bovine, mouse, rat) H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
L-Phenylalanine, L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-
Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe ((2) Due to the presence of a Gln in N-terMinal position this peptide can contain the pyroglutaMic forM)
Molecular Formula
C69H111N23O16S
MDL Number
MFCD02094627
MOL File
217082-58-1.mol
Molecular Weight
1550.83

Chemical Properties

density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
−20°C

solubility 
Soluble in PBS (pH 7.2) at approximately 10 mg/ml.
pka
3.56±0.10(Predicted)

Safety Data

WGK Germany 
3

Hazard Information

Uses
The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM (the EC50 values for apelin-17 and apelin-36 are 2.5 and 20 nM, respectively). It acts primarily in the periphery and central nervous system, playing important roles in regulating cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity. Unlike apelin-36, apelin-13 poorly blocks the entry of human immunodeficiency virus into cells.
General Description
Apelin is a regulatory peptide and a ligand of the APJ receptor. It is a member of the G protein-coupled receptor family. Apelin and APJ are broadly dispersed in the body.

Biochem/physiol Actions
Apelin plays physiological roles in the cytoprotection of many internal organs. It is used to treat insulin resistance and hypertension, but it may also can act as a negative factor. Apelin also regulates cardiovascular diseases.
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