Hazard Information
Uses
Magrolimab (Hu5F9-G4) is a humanized anti-CD47 antibody. Magrolimab can block the "don't eat me" signal of CD47, thereby promoting macrophage mediated phagocytosis. Magrolimab has antitumor activity in malignant bone tumors and breast cancer[1][2][3].
in vivo
Magrolimab (12-100 μg; once daily; 10 days; i.p.) exhibits anti-tumor activity in mice with Ewing's sarcoma[1]. Magrolimab (250 μg; once every two days; 7 weeks; i.p.) combined with trastuzumab (HY-P9907) can eliminate HER2 positive breast cancer cells in breast cancer mice and overcome the tolerance of trastuzumab[2].
| Animal Model: | Humanized and non-humanized ES xenograft NSG-SGM3 mice[1]. |
| Dosage: | 12-100 μg |
| Administration: | Intraperitoneal injection (i.p.); once daily; 10 days |
| Result: | Inhibited tumor growth and lung metastasis, and prolonged animal survival time. |
| Animal Model: | 4-8 weeks old NSG female breast cancer mouse model[2]. |
| Dosage: | 250 μg |
| Administration: | Intraperitoneal injection (i.p.); once every two days; 7 weeks (implanted GFP/luciferase BT474 cells into the left mammary fat pad of female mice) |
| Result: | Restricted the Growth of HER2 ADCC-Tolerant Tumors. |
References
[1] Luo W, et al. A humanized orthotopic mouse model for preclinical evaluation of immunotherapy in Ewing sarcoma. Front Immunol. 2023 Oct 6;14:1277987. DOI:10.3389/fimmu.2023.1277987
[2] Upton R, et al. Combining CD47 blockade with trastuzumab eliminates HER2-positive breast cancer cells and overcomes trastuzumab tolerance. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2026849118. DOI:10.1073/pnas.2026849118
[3] Liu Y, et al. PARP inhibition synergizes with CD47 blockade to promote phagocytosis by tumor-associated macrophages in homologous recombination-proficient tumors. Life Sci. 2023 Aug 1;326:121790. DOI:10.1016/j.lfs.2023.121790
[2] Upton R, et al. Combining CD47 blockade with trastuzumab eliminates HER2-positive breast cancer cells and overcomes trastuzumab tolerance. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2026849118. DOI:10.1073/pnas.2026849118
[3] Liu Y, et al. PARP inhibition synergizes with CD47 blockade to promote phagocytosis by tumor-associated macrophages in homologous recombination-proficient tumors. Life Sci. 2023 Aug 1;326:121790. DOI:10.1016/j.lfs.2023.121790
Supplier
Shanghai YuanYe Biotechnology Co., Ltd.
Telephone021-61312847; 18021002903
Websitehttp://www.shyuanye.com
ShangHai Biochempartner Co.,Ltd
Telephone177-54423994 17754423994
Websitehttps://www.biochempartner.com
Guangzhou Hongyuan Chemical Co.,Ltd
Telephone 15817493340
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1222417/0_EN.htm
Wuhan Chemstan Biotechnology Co., Ltd.
Telephone027-65317797 15926423062
Websitehttp://www.chemstan.com/
Bide Pharmatech Ltd.
Telephone400-1647117 13681763483
Websitehttps://www.bidepharm.com/
TargetMol Chemicals Inc.
Telephone 4008200310
Websitehttps://www.targetmol.cn/
Biolab Reagents
Telephone18108604356
Websitehttps://www.biolabreagent.com/
Wuhan Jingkangen Biomedical Technology Co., Ltd
Telephone13720134139 086-15871494362 13720134139
Websitehttps://www.jknbiochem.com
Shanghai Yifei Biotechnology Co. , Ltd.
Telephone021-65675885 18964387627
Websitehttp://www.efebio.com
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Telephone400-6206333 13167063860
Websitehttp://www.aladdin-e.com/
Shanghai jerryxing Biomedical Technology Co., Ltd
Telephone17721492509; 17721492509
Websitehttp://www.jrxbiochem.com/
Changsha Fuzhen Biotechnology Co.，LTD
Telephone0731-13823398 15111215862
Websitehttps://www.chemicalbook.com/supplier/25777903/
Olix (Shanghai) Pharmaceutical Technology Co., Ltd
Telephone17316404525 17316404525
Websitehttps://www.olix.cn
Wanxin Biotechnology (Jiaxing) Co., LTD
Telephone0573-83568680 18057391398
Website
Atagenix Laboratories
Telephone027-87008169 17762441161
Websitehttps://www.abinscience.com/
Sangon Biotech (Shanghai) Co.,Ltd.
Telephone400-821-026
Websitehttp://www.sangon.com
AntibodySystem Laboratories SAS
Telephone 33175446423
Websitehttp://www.antibodysystem.com
Biosynth Biological Technology (Suzhou) Co Ltd
Telephone 51288865780
Websitehttp://www.biosynth.com
1of4
PROMPT×
PROMPT
The What'sApp is temporarily not supported in mainland China
The What'sApp is temporarily not supported in mainland China
Cancel
Determine