2162962-69-6

CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; K_d = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells with an IC₅₀ value of 0.7 nM.

CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

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