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Phyllodulcin is an orally active sweetener found in Hydrangea macrophylla var. thunbergii. Phyllodulcin acts as a non-selective phosphodiesterase inhibitor and exerts anti-allergic effects by suppressing lymphocyte activation. Phyllodulcin can be used to combat obesity by regulating levels of leptin, fat browning-related genes, and hypothalamic BDNF-TrkB signaling[1][2].

ChEBI: Phyllodulcin is a hydroxybenzoic acid.

[1] Liu J, et al. Medicinal flowers. XXXX . Structures of dihydroisocoumarin glycosides and inhibitory effects on aldose reducatase from the flowers of Hydrangea macrophylla var.thunbergii. Chem Pharm Bull (Tokyo). 2013;61(6):655-61. DOI:10.1248/cpb.c13-00160
[2] Kim E, et al. Phyllodulcin, a Natural Sweetener, Regulates Obesity-Related Metabolic Changes and Fat Browning-Related Genes of Subcutaneous White Adipose Tissue in High-Fat Diet-Induced Obese Mice. Nutrients. 2017 Sep 21;9(10):1049. DOI:10.3390/nu9101049