2144-08-3
| Name | 2,3,4-Trihydroxybenzaldehyde |
| CAS | 2144-08-3 |
| EINECS(EC#) | 218-404-2 |
| Molecular Formula | C7H6O4 |
| MDL Number | MFCD00003325 |
| Molecular Weight | 154.12 |
| MOL File | 2144-08-3.mol |
Chemical Properties
| Appearance | light brown to beige-brown powder |
| Melting point | 159-161 °C (lit.) |
| Boiling point | 237.46°C (rough estimate) |
| density | 1.3725 (rough estimate) |
| refractive index | 1.6400 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| form | Powder |
| pka | 7.41±0.23(Predicted) |
| color | Light brown to beige-brown |
| Water Solubility | 1.541g/L at 25℃ |
| Sensitive | Air Sensitive |
| BRN | 2328658 |
| InChI | 1S/C7H6O4/c8-3-4-1-2-5(9)7(11)6(4)10/h1-3,9-11H |
| InChIKey | CRPNQSVBEWWHIJ-UHFFFAOYSA-N |
| SMILES | [H]C(=O)c1ccc(O)c(O)c1O |
| LogP | 1.25 |
| CAS DataBase Reference | 2144-08-3(CAS DataBase Reference) |
| EPA Substance Registry System | 2144-08-3(EPA Substance) |
Safety Data
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | |
| Safety Statements | |
| WGK Germany | 2 |
| RTECS | CU8439800 |
| TSCA | Yes |
| REACH Registrations | Active |
| HS Code | 29124990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
This method takes pyrogallol as an initial raw material. It comprises three steps of phenolic hydroxyl protection, formylation, and deprotection: protecting two adjacent phenolic hydroxyl groups in the pyrogallol to obtain 4-hydroxybenzo[d][1,3]dioxol-2-one, then performing formylation to obtain 7-hydroxy-2-oxobenzo[d][1,3]dioxole-4-carbaldehyde, and finally removing a protecting group to get a target 2,3,4-trihydroxybenzaldehyde.