2140807-24-3

Name	1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-
CAS	2140807-24-3
Molecular Formula	C22H29N3O10S
Molecular Weight	527.54
MOL File	2140807-24-3.mol

Synonyms

Thalidomide-NH-PEG4-Ms Pomalidomide-NH-PEG4-Ms 1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-

show less show more

Hazard Information

Biological Activity

Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1]. XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].

References

[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.

Supplier

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840 18892239720

Websitehttp://www.jm-bio.com/

Xi'an Confluore Biological Technology Co., Ltd.

Telephone+86-156-80926068 +86-15680926068

Websitehttp://www.confluore.cn/

Jilin Province Woda Biotechnology Co., Ltd.

Telephone 13504435624

Websitehttps://www.wodapro.com

DC Chemicals

Telephone021-58447131 13564518121

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm

Xian confluore Biological Technology Co., Ltd.

Telephone+86-15680926068 +86-15680926068

Websitehttp://www.confluore.com/

Related Products

2360530-43-2 2140807-23-2

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy