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• Synthesis

  Under a nitrogen atmosphere, 10% palladium solid on carbon was added to a BOM-protected uridine derivative (1 equivalent) in a mixed solution of isopropanol and water (10:1 ratio). HCO2H (0.5%) was then added to the reaction system. Hydrogen gas was introduced into the reaction mixture using a double-folded balloon. After the reaction was complete, the palladium solid on carbon was removed by diatomaceous earth filtration, and the reaction mixture was washed with isopropanol. All volatiles were rotary evaporated under vacuum to generate the HCO2H-amine salt. The crude mixture was then dissolved in chloroform and washed with an aqueous sodium bicarbonate solution. The combined organic layers were dried with anhydrous sodium sulfate, and the combined organic extracts were evaporated under vacuum. The residue was purified by silica gel chromatography to obtain the target product, 2'-methoxyuridine.

  

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