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N-Mal-N-bis(PEG2-NH-Boc) is a branched maleimide reagent with a terminal maleimide group and two terminal Boc protected amino groups. Maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule . Boc can be deprotected under acidic conditions.

N-Mal-N-bis(PEG2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs; Alkyl/ether

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005