2100306-51-0

N-Mal-N-bis(PEG2-t-butyl ester) is a branched maleimide ester. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The t-butyl pester can be hydrolyzed under mild acidic conditions.

N-Mal-N-bis(PEG2-C2-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005