ChemicalBook CAS DataBase List 21215-62-3

21215-62-3

Name	CALCITONIN, HUMAN
CAS	21215-62-3
EINECS(EC#)	244-276-2
Molecular Formula	C151H226N40O45S3
MDL Number	MFCD00167520
Molecular Weight	3417.85
MOL File	21215-62-3.mol

Synonyms

calcitonin M Unii-I0io929019 Einecs 244-276-2 human C carcinoma CALCITONIN, HUMAN hCT Thyrocalcitonin CALCITONIN M, HUMAN* THYROCALCITONIN HUMAN Human calcitonin (1-32) Calcitonin, human synthetic 1,7-Dicarbacalcitonin【human】 Calcitonin Human,recombinant Calcitonin,huMan,Calcitonin,hu Calcitonin, human, for bioassay calcitonin m, human c carcinoma Calcitonin, human reduced cyclic(1→7)-disulfide CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-NH2 (DISULFIDE BRIDGE: 1-7) Calcitonin M, human C carcinoma, Calcitonin, human reduced cyclic (1-7)-disulfide, hCT, Thyrocalcitonin CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2 CYST-GLY-ASN-LEU-SER-THR-CYST-MET-LEU-GLY-THR-TYR-THR-GLN-AS-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO NH2 H-CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2 CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2 HUMAN H-CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2 (DISULFIDE BRIDGE: 1-7)

Chemical Properties

Boiling point	3061.8±65.0 °C(Predicted)
density	1.326±0.06 g/cm3(Predicted)
RTECS	XP3560000
storage temp.	−20°C
solubility	Soluble in DMSO
form	powder
color	White to off-white
biological source	synthetic (organic)
Water Solubility	Soluble to 2 mg/ml in water
Merck	13,1642
Sequence	Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 (Disulfide bridge:Cys1-Cys7)
InChIKey	LDVRMNJZLWXJPL-JKQNMTHDSA-N

Safety Data

Safety Statements	22-24/25 less more
WGK Germany	3
Storage Class	11 - Combustible Solids

Hazard Information

Uses

Calcitonin human has been used to study its ability to stimulate cAMP production post transfection in mammalian cell by activating human CALCRL (calcitonin receptor like receptor gene)- receptor activity-modifying protein 1 (RAMP1) and CTR (calcitonin receptor).

Uses

Decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. A carrier peptide that can be used to internalize fusion proteins

Uses

Regulator (calcium).

Brand name

Calcimar (Rhone- Poulenc Rorer);.

Biochem/physiol Actions

Calcitonin, also referred to as thyrocalcitonin, is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compared to serum. It acts as a first messenger and hence regulates the the production of cAMP as well as mammalian sperm function. It also facilitates the regulation of different isoforms of adenylyl cyclase.

in vivo

Calcitonin (oral gavage; 2 mg/kg; once daily; 9 w) can inhibit cartilage degradation and prevent cartilage erosion^[3].

Animal Model:	Female Sprague-Dawley rats^[3]
Dosage:	2 mg/kg
Administration:	Oral gavage; 2 mg/kg; once daily; 9 weeks
Result:	Suppressed ovariectomy-induced cartilage degradation (P<0.001) compared with the carrier control. Prevented cartilage erosion compared with treatment with the carrier alone (P<0.01), and the extent of erosions was comparable with that in sham-operated animals.

storage

Store at -20°C

Supplier

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