ChemicalBook CAS DataBase List 2120398-39-0

2120398-39-0

Name	5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile
CAS	2120398-39-0
Molecular Formula	C18H18FN7O2
MDL Number	MFCD34470748
Molecular Weight	383.38
MOL File	2120398-39-0.mol

Chemical Properties

storage temp.

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Animal Model:	Baib/c nude mice with HT-29 colon cancer cells^[1]
Dosage:	40 mg/kg
Administration:	IV; twice a week for 21 days
Result:	Inhibited tumor growth.

Animal Model:	Male SD rats (280-350 g)^[1]
Dosage:	10 mg/kg
Administration:	Via tail vein intravenous injection
Result:	Displayed a longer half-life (T_1/2=3.8 hours) and higher exposure (CL=2.3 L/hr?kg; V_ss=6.4 L/kg; AUC=4531 ng/ml?h).