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Gly-PEG3-amine, TFA salt is a PEG linker containing a glycine residue and an amine group. The amine groups can be further reacted with carboxylic acids, activated NHS esters and other carbonyl groups. The hydrophilic PEG linker increases the water solubility properties of the compound.

Gly-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Cleavable Linker

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268