2109450-40-8

RN 9893 Hydrochloride is a selective TRPV4 inhibitor.

RN-9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4. RN-9893 has IC50 values of 420 nM660 nMand 320 nM for humanr at and mouse TRPV4 receptorsrespectively. RN-9893 shows excellent selectivity over related TRP receptors with no inhibition of TRPV1 at a concentration of 10 μMan IC50 >30 μM against TRPV3an IC50 of approximately 30 μM against TRPM8and also good selectivity using 54 binding assays against common biological targets.