2091134-35-7

JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1].

JAK1: 85 nM (IC₅₀); JAK2: 12.8 μM (IC₅₀)

Store at -20°C

[1] Annika Birgitta Margareta ?STRAND, et al. Compounds and methods for inhibiting jak.