2082743-96-0

Name	Guanosine, [P(R)]-2'-deoxy-2'-fluoro-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thio-β-D-arabino-adenylyl-(3'→5')-3'-deoxy-3'-fluoro-, cyclic nucleotide
CAS	2082743-96-0
Molecular Formula	C20H22F2N10O9P2S2
Molecular Weight	710.52
MOL File	2082743-96-0.mol

Synonyms

MK-1454 Ulevostinag Ulevostinag (MK-1454) Guanosine, [P(R)]-2'-deoxy-2'-fluoro-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thio-β-D-arabino-adenylyl-(3'→5')-3'-deoxy-3'-fluoro-, cyclic nucleotide

show less show more

Chemical Properties

Boiling point	985.8±75.0 °C(Predicted)
density	2.43±0.1 g/cm3(Predicted)
form	Solid
pka	-0.89±0.70(Predicted)
color	White to off-white

Hazard Information

Uses

Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research[1].

in vivo

Ulevostinag (MK-1454) (5 μg, 20 μg for intratumorally) can activate tumor-specific immune responses in MC38 injected tumors and inhibit tumor growth at untreated, distal sites^[1].
Ulevostinag (MK-1454) (4 μg for intratumorally on day 0, 3 and 7) results in complete tumor regression and enhances the efficacy of anti-PD1 therapy in MC38 and B16F10 tumor mice model^[1].

Animal Model:	MC38 colon adenocarcinoma tumor-bearing mice^[1]
Dosage:	5 μg, 20 μg
Administration:	intratumorally
Result:	Regressed the injected (right) tumors and was detected in injected and noninjected tumors as well as plasma when dosed at 20 μg. Elevated IFN-β and proinflammatory cytokines IL-6 and TNF-α in injected tumors.

Animal Model:	MC38 and B16F10 tumor mice model^[1]
Dosage:	4 μg
Administration:	intratumorally
Result:	Improved tumor growth inhibition with 7 CRs out of 10 mice over 28 days.

References

[1] Zawit M, et al. Current status of intralesional agents in treatment of malignant melanoma. Ann Transl Med. 2021 Jun;9(12):1038. DOI:10.21037/atm-21-491
[2] Gogoi H, et al. The Age of Cyclic Dinucleotide Vaccine Adjuvants. Vaccines (Basel). 2020 Aug 13;8(3):453. DOI:10.3390/vaccines8030453
[3] Chang W, et al. Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer. J Med Chem. 2022 Apr 14;65(7):5675-5689. DOI:10.1021/acs.jmedchem.1c02197

Supplier

NewCan Biotech Limited

Telephone+86-0571-86912261 +86-15658003402

Websitehttps://www.newcanbio.com/

Shanghai Tachizaki Biomedical Research Center

Telephone 18014399201

Websitehttp://www.chemlab-tachizaki.com/

Shanghai meikai technology co., ltd

Telephone021-68689288 15300790979

Websitehttps://www.mkbio.com.cn/

Nantong HI-FUTURE Biology Co., Ltd.

Telephone +86-18051384581

Websitehttps://www.chemhifuture.com/

Related Products

1951464-79-1 2082743-96-0

2082743-98-2 849214-04-6

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy