Supplier Related Products Identification Chemical Properties Safety Data Questions And Answer
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20575-57-9

Supplier Related Products Identification Chemical Properties Safety Data Questions And Answer

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Identification

Name
CALYCOSIN
CAS
20575-57-9
Synonyms
Clycosin
CALYCOSIN
CALYCOSIN(SH)
Astraisoflavone
Calycosin (Cyclosin)
Calycosin 20575-57-9
3'-HYDROXYFORMONONETIN
Calycosin >=98% (HPLC)
7,3'-DIHYDROXY-4'-METHOXYISOFLAVONE
3',7-DIHYDROXY-4'-METHOXYISOFLAVONE
Calycosin, 98%, from Astragalus membranaceus Bunge
7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1-benzopyran-4-one
3-(3-Hydroxy-4-methoxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one
7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-
Molecular Formula
C16H12O5
MDL Number
MFCD00210598
MOL File
20575-57-9.mol
Molecular Weight
284.26

Chemical Properties

Melting point 
245~247℃
Boiling point 
536.8±50.0 °C(Predicted)
density 
1.420±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
methanol: soluble1mg/mL, clear, colorless
form 
powder
pka
6.94±0.20(Predicted)
color 
white to light yellow
InChIKey
ZZAJQOPSWWVMBI-UHFFFAOYSA-N

Safety Data

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 3462 6.1 / PGIII
WGK Germany 
3
HS Code 
2932996560
Hazardous Substances Data
20575-57-9(Hazardous Substances Data)

Questions And Answer

Definition

Calycosin is an O-methylated isoflavone. It can be isolated from Astragalus membranaceus Bge. var. mongholicus and Trifolium pratense L. Calycosin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position. It has a role as a metabolite and an antioxidant. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It derives from an isoflavone. It is a conjugate acid of a calycosin(1-).


Pharmaceutical Properties

The potential pharmaceutical properties of calycosin in the treatment of tumors, inflammation, stroke, and cardiovascular diseases have gained increasing attention in the recent years. The literature survey showed that calycosin exhibits promising effects for the treatment of several diseases and that these effects may be due to its isoflavonoid and phytoestrogenic properties. The effects of calycosin most likely result from its interaction with the ER receptors on the cell membrane and the modulation of the MAPK signaling pathway.
Through its effect on this pathway, calycosin can regulate several cell activities, such as apoptosis and angiogenesis, which enables its therapeutic functions. 


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