2044701-99-5

HDAC3-IN-1 (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM[1].

HDAC3: 5.96 ± 0.0 nM (IC₅₀); HDAC1: 36.4 ± 0.2 nM (IC₅₀); HDAC2: 89.9 ± 0.7 nM (IC₅₀)

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[1] Moreno-Yruela C, Olsen CA. Determination of Slow-Binding HDAC Inhibitor Potency and Subclass Selectivity. ACS Med Chem Lett. 2022 Mar 16;13(5):779-785. DOI:10.1021/acsmedchemlett.1c00702