204140-01-2

MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC₅₀s = 0.9 nM for both). It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC₅₀s = 43, 23, and 920 nM, respectively). MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.

A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13

MMP-9: 0.9 nM (IC₅₀); MMP-13: 0.9 nM (IC₅₀); MMP-1: 43 nM (IC₅₀); MMP-3: 23 nM (IC₅₀); MMP-7: 931 nM (IC₅₀)