BemPPOX is a potent inhibitor of DGL. BemPPOX is a candidate to efficiently regulate gastrointestinal lipolysis.
Uses
BemPPOX is an orally active, potent dog gastric lipase (DGL) inhibitor with Xl50 (the inhibitor molar excess leading to 50% lipase inhibition) of 0.5. BemPPOX is also a good inhibitor of GPLRP2 (xl50=0.64). BemPPOX efficiently regulates the gastrointestinal lipolysis and slows down the overall lipolysis process in rats. BemPPOX has the potential for obesity research[1].
References
[1] Vanessa Point, et al. Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis. Eur J Med Chem. 2016 Nov 10:123:834-848. DOI:10.1016/j.ejmech.2016.08.009
