Uses
In order to establish defined biomacromolecular systems for mineralised tissue applications, type I collagen was functionalised with 1,3-phenylenediacetic acid (Ph) and investigated at the molecular, macroscopic and functional levels. The solvothermal reactions of 1,2-bis(imidazol-1?-yl)ethane (bime), 1,3-phenylenediacetic acid, 1,4-phenylenediacetic acid), 1,2-phenylenediacetic acid with different metal ions gave rise to four novel helical coordination polymers.
Synthesis
General procedure for the synthesis of 1,3-benzenediacetic acid from 1,3-benzenediacetonitrile: 25 mL of concentrated sulfuric acid was diluted with 35 mL of water, followed by the addition of 24 g of 1,3-benzenediacetonitrile, and the reaction was carried out at reflux for 1 hour and 30 minutes. Upon completion of the reaction, the reaction mixture was poured into 200 mL of ice water and the precipitated crystals were collected by filtration and washed with cold water. Finally, the resulting crystals were dried under reduced pressure at 100 °C for 1 h to give 27 g of 1,3-benzenediacetic acid.
References
[1] Organic Process Research and Development, 2011, vol. 15, # 4, p. 871 - 875
[2] Chemische Berichte, 1987, vol. 120, p. 411 - 420
[3] Journal of the Chemical Society, 1932, p. 1477
[4] Journal of the Chemical Society, 1933, p. 1592,1596
[5] Journal fuer Praktische Chemie (Leipzig), 1932, vol. <2> 135, p. 1,4
