1962925-28-5

CCT241533 dihydrochloride is a potent and selective ATP competitive inhibitor of CHK2 with an IC50 of 3 nM and Ki of 1.16 nM[1].

Chk2: 3 nM (IC₅₀); Chk1: 245 nM (IC₅₀); Chk2: 1.16 nM (Ki)

Desiccate at RT

[1] Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72. DOI:10.1158/0008-5472.CAN-10-1252
[2] Caldwell JJ, et al. Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90. DOI:10.1021/jm101150b