194935-38-1

Prostaglandin E₂ ethanolamide (PGE₂-EA) is an analog of PGE₂ with improved water solubility and stability. PGE₂-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; ) and acts as an agonist at E prostanoid (EP) receptors 1-4 (K_is = 2.45, 0.46, 0.2, and 0.51 μM, respectively). It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC₅₀s = 5.7 and 4.7 μM, respectively). PGE₂-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes. Ex vivo, PGE₂-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.

Prostaglandin E2 Ethanolamide-d4 is the isotope labelled analogue of Prostaglandin E2 Ethanolamide, an analogue of Prostaglandin E2 (P838610). Prostaglandin E2 is most common and most biologically potent of mammalian prostaglandins.

ChEBI: Prostaglandin E2 ethanolamide is a prostanoid.