194423-15-9

Potent, cell permeable, irreversible, and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50=700pM). Antitumor agent in vivo.

ChEBI: A member of the class of quinazolines carrying bromoanilino and acrylamido substituents at positions 4 and 6 respectively.

PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.

This photosensitive quinazoline (FW = 369.22 g/mol), also known as 4-[ (3- bromophenyl) amino]-6-acrylamido-quinazoline, irreversibly inhibits epidermal growth factor receptor (EGFR) protein-tyrosine kinase, IC50 = 0.7 nM. See also PD 174265

EGFR