ChemicalBook CAS DataBase List 1931994-80-7

1931994-80-7

Name	IRAK4 inhibitor
CAS	1931994-80-7
Molecular Formula	C22H25F3N4O3
MDL Number	MFCD32663139
Molecular Weight	450.45
MOL File	1931994-80-7.mol

Chemical Properties

Boiling point	556.7±50.0 °C(Predicted)
density	1.32±0.1 g/cm3(Predicted)
form	Solid
pka	11.67±0.43(Predicted)
color	White to light yellow

Hazard Information

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Shanghai XingMo Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Xiushi Biomedical Co., LTD

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Hebei Weite Medical Technology Co., Ltd

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Hubei Kele Fine Chemical Co., Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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Websitehttp://www.efebio.com

PharmaBlock Sciences (Nanjing), Inc.

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https://hanhongsci.com/

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Shanghai jerryxing Biomedical Technology Co., Ltd

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Hubei Yihua New Materials Technology Co., Ltd.

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Guangzhou Ruidi Biotechnology Co., Ltd.

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Suzhou ARTK Medchem Co., Ltd.

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Wuhan Topule Biopharmaceutical Co., Ltd

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Animal Model:	Female Balb/c mice (aged 6–7 weeks), LPS-induced ARDS mouse model^[1]
Dosage:	150 mg/kg
Administration:	Oral administration, 30 min before LPS modeling or twice 4 h and 12 h after LPS modeling
Result:	Remarkably decreased inflammatory cells infiltrating lung tissue and neutrophil count in BALF. Effectively reduced the numbers of total T cells, monocyte, and macrophages. Largely preserved the signatures of na?ve lymphocytes and stromal cells such as endothelial cells, chondrocytes, and smooth muscle cells. Regulated inflammation and innate immunity genes more efficiently than Dexamethasone (HY-14648).

1931994-80-7

Chemical Properties

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Description

Uses

in vivo

IC 50

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