Description
R 115777 is a farnesyl transferase inhibitor.
Uses
(Rac)-Tipifarnib ((Rac)-IND 58359; (Rac)-R115777) is a potent farnesyl protein transferase inhibitor that specifically targets the pro-tailation process of Ras proteins. (Rac)-Tipifarnib showed significant in vivo antitumor effects after oral administration to mice[1].
References
[1] Venet M, et al. Farnesyl protein transferase inhibitor ZARNESTRA? R115777-History of a discovery[J]. Current Topics in Medicinal Chemistry, 2003, 3(10): 1095-1102.
