191102-87-1

GGTI-2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells.

Cell permeable: yes''Primary Target
GGTase-I''Product does not compete with ATP.''Reversible: no''Target IC50: 500 nM in blocking the geranyl-geranylation of Rap1A