ChemicalBook CAS DataBase List 189279-58-1

189279-58-1

Name	ABT-492
CAS	189279-58-1
Molecular Formula	C18H12ClF3N4O4
MDL Number	MFCD09955301
Molecular Weight	440.76
MOL File	189279-58-1.mol

Synonyms

WQ3034 CS-711 CS-2335 ABT-492 RX-3341 Delafloxacin Delafloxacinum ABT492/ABT-492 ABT-492(WQ-3034) ABT-492/Delafloxacin Delafloxacin, ABT-492 Delafloxacin Impurity Delafloxacin Free Acid DELAFLOXACIN;RX-3341;WQ-3034;ABT492 DELAFLOXACIN;DELAFLOXACINUM;RX-3341;WQ-3034;ABT492;ABT 492 DELAFLOXACINUM; RX-3341; WQ-3034; ABT492; ABT 492; ABT-492;WQ3034;WQ 3034 1-(6-aMino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylic acid 1-(6-Amino-3,5-difluoro-pyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-quinolin-3-carboxylic acid 3-Quinolinecarboxylic acid, 1-(6-aMino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo- 3-(6-Amino-3,5-difluoro-pyridin-2-ylamino)-2-{2,5-difluoro-4-[3-(3-methyl-2-oxo-butyl)-cyclobutyl]-benzoyl}-acrylic acid ethyl ester

Chemical Properties

Melting point	238-241℃
Boiling point	698.5±55.0 °C(Predicted)
density	1.796
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Very Slightly, Heated, Sonicated)
form	powder
pka	5.49±0.50(Predicted)
color	white to beige
InChI	InChI=1S/C18H12ClF3N4O4/c19-12-13-7(1-9(20)14(12)25-3-6(27)4-25)15(28)8(18(29)30)5-26(13)17-11(22)2-10(21)16(23)24-17/h1-2,5-6,27H,3-4H2,(H2,23,24)(H,29,30)
InChIKey	DYDCPNMLZGFQTM-UHFFFAOYSA-N
SMILES	N1(C2=NC(N)=C(F)C=C2F)C2=C(C=C(F)C(N3CC(O)C3)=C2Cl)C(=O)C(C(O)=O)=C1
CAS DataBase Reference	189279-58-1

Hazard Information

Uses

Delafloxacin is a potent agent and broad-spectrum anionic fluoroquinolone against Streptococcus pneumoniae and diverse group of pathogens.

Biochem/physiol Actions

Delafloxacin is a fluoroquinolone antibiotic active against both Gram-negative and Gram-positive bacteria such as MRSA. Delafloxacin targets both DNA gyrase and topoisomerase IV, inhibiting DNA synthesis. Unlike most fluoroquinolones, delafloxacin is weakly acidic, which increases its potency in an acidic environments such as those existing in inflammatory cells and in skin and soft tissue infections. Delafloxacin shows good activity against most fluoroquinolone-resistant strains.

in vivo

Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective against S. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log₁₀ CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log₁₀ kill from initial burden for all S. aureus strains^[1].
Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t_1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively)^[1].

Animal Model:	Mice with a neutropenic murine lung infection model (four S. aureus , four S. pneumoniae, and four K. pneumoniae strains)^[1]
Dosage:	The total daily doses vary from 0.156 to 640 mg/kg/24 h
Administration:	0.03 to 160 mg/kg are administered every 6 h (q6h) to infected mice by subcutaneous injection
Result:	Inhibited S. aureus strains ATCC 29213, ATCC 33591, MW2, R2527 with MICs of 0.008, 0.008, 0.004, and 0.004 mg/L, respectively. Inhibited S. pneumoniae strains ATCC 10813, ATCC 49619, 145, and 1329 with MICs of 0.03, 0.125, 0.016, and 0.016 mg/L, respectively. Inhibited K. pneumonia strains ATCC 43816, 4105, 4110, and 81-1260A with MICs of 0.06, 1, 0.5, and 0.06 mg/L, respectively.

Animal Model:	Neutropenic mice^[1]
Dosage:	2.5, 10, 40, and 160 mg/kg; 0.2 mL
Administration:	Subcutaneous injection; 24 h
Result:	The maximum drug concentrations (C_max) concentrations ranged from 2 to 71 mg/L. AUC_0-∞ values ranged from 2.8 to 152 mg?h/L and were linear across the 2.5- to 160-mg dosing range. The elimination half-life (t_1/2) ranged from 0.7 to 1 h.

IC 50

Quinolone

storage

Store at -20°C

Spectrum Detail

Supplier

Shanghai Boyle Chemical Co., Ltd.

Telephone

Websitehttp://www.boylechem.com

Chembest Research Laboratories Limited

Telephone021-20908456

Websitehttp://www.BioChemBest.com

NCE Biomedical Co.,Ltd.

Telephone4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Telephone400-6206333 13167063860

Websitehttp://www.aladdin-e.com/

TargetMol Chemicals Inc.

Telephone021-021-33632979 15002134094

Websitehttps://www.targetmol.cn/

CEG Chemical Science&Technology Co., Ltd.

TelephoneMobile:13665161512

Websitehttp://www.cegchemical.com

Bide Pharmatech Ltd.

Telephone400-164-7117 18317119277

Websitehttp://www.bidepharm.com

Changzhou Yuanda Pharmaceutical Chemical Co., Ltd.

Telephone0519-83984084

Websitehttp://www.ydpharm.com

Shanghai Macklin Biochemical Co.,Ltd.

Telephone15221275939 15221275939

Websitehttp://www.macklin.cn

Hangzhou J&H Chemical Co., Ltd.

Telephone0571-87396432

Websitehttp://www.jhechem.com

Shanghai HuanChuan Industry Co.,Ltd.

Telephone021-61478794

Websitehttp://www.hcshhai.com

AdooQ Bioscience CHINA

Telephone025-58849295

Websitehttp://www.adooq.cn

Hunan Cangood Medical Technology Ltd.

Telephone400-026-9899

Websitehttp://www.cangood.cn

LETOPHARM LIMITED

Telephone+86-21-5821 5861

Websitehttp://www.letopharm.com

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Shanghai Lollane Biological Technology Co.,Ltd.

Telephone021-52996696，15000506266 15000506266

Websitehttp://www.bioll.com

Shanghai Mixiu Chemical Co., Ltd.

Telephone 18101936766

Websitehttp://www.shmychem.com

Nanjing XiZe Biotechnology CO., Ltd.

Telephone025-66023220 15250997978

Websitehttp://www.njxizebio.com

1of4

Related Products

Send Inquriy