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• Flavors

  Cinnamonitrile is also  known as styrene cyanide, is an excellent synthetic spice,it has a strong spicy aroma like cinnamon and floral nuances, colorless or pale yellow viscous liquid, it is chemically stable, light, heat or acid, alkaline etching can not make it change. There are no toxic side effects on the human body, there is no stimulation in contact with skin ,there are no allergic reactions, compared with cinnamic aldehyde, cinnamonitrile has the stronger ability through the hair, the aroma is strong and lasts for a long time, potential   skin irritation and toxicity are smaller than  cinnamic aldehyde,it is the ideal substitute for cinnamon oil and cinnamic aldehyde,it can be used in daily chemical flavor formula,it is mainly used for soap flavor and fragrance detergent formulations, the amount is less than 2%. IFRA has no restrictions. Since cinnamonitrile has a unique chemical structure,it can occur Friedel, addition, reduction, hydrolysis reactions,it is also widely be used  in the pharmaceutical, fine chemical industry  . According to the information provided by RIFM, acute toxicity data of cinnamonitrile: oral LD504.15g/kg (rat), skin test LD50> 5g/kg (rabbit). Cinnamonitrile can be made by condensation of acetonitrile with benzaldehyde in the presence of potassium hydroxide solution  ; or it can be made by the  first transformation of cinnamaldehyde  into oxime, then  by the dehydration following.;

• Chemical properties

  Light transparent pale yellow liquid with a strong, warm spicy fragrance.;

• Antibacterial effects

  Nanjing University Department of Biology and the Institute of Hydrobiology of the Chinese Academy of Sciences teachers measured the inhibitory effects of   plant pathogens Altornaria tenuis Nees and Rhizopus nigricans on their own separate identification , skin addiction germs Epidermophyton floccosum, Trichophytoa gypsoum, Trichophyton rubrum, Microsporum gypseum, as well as 22 kinds of mold (  18 kinds of common food, fruits and other mold rot fungus, four kinds of human shallow filamentous fungus), the results show that  cinnamonitrile has a high nitrile  antimicrobial effect,it has the role of antibiotics, but  it is not an antibiotic,its mold inhibition effect is good, it has broad  antibacterial spectrum , and anthelmintic effect. Experiments show that the breeding of bacteria in the production process needs folic acid to participate in  , cinnamonitrile  structure is similar to PABA, they are competitive in binding with dihydrofolate synthase, which inhibits the activity of  dihydrofolate synthase, impeding dihydrofolate synthesis, thus affecting the synthesis of folic acid, inhibiting bacterial growth propagation; and it can interfere with the synthesis of some bacteria, and the synthesis of the enzyme needed for cell division to inhibit and impact the synthesis of bacterial RNA , which reduces the permeability of the cell membrane thus affects the normal metabolism of bacteria, resulting in death, so bactericidal effect  are more thorough . What is more amazing  is that the human body does not produce Cinnamonitrile  dependence, it can eliminate bacteria tribes, but it will not break the constraints  relationship between bacteria and thus does not produce resistance. Cinnamonitrile  itself is a spice, there are no toxic side effects on the human body, in contact with skin no stimulation, no allergic reactions. Experts said excitedly,that with deepening study of the cinnamonitrile  antibacterial  aspect  , cinnamonitrile is expected to completely replace antibiotics, and become the "Terminator"of antibiotics.;

• Application

  • Cinnamonitrile  is an extremely stable nitrile spices, much like the natural aroma of cinnamon.
  • For the synthesis of pharmaceuticals, perfumes and electronic chemicals.
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• Preparation

  Cinnamic aldehyde reacts with hydroxylamine hydrochloride in the presence of pyridine by the addition-elimination reaction to produce aldehyde oxime, then it boils with toluene azeotropic and after dehydration to generate  cinnamonitrile.;

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