187888-07-9

Endostatin is a naturally occurring 20kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. The gene encoding it is localized on human chromosome 21q22.3. Anti-Collagen XVIII α1 Antibody detects endogenous levels of total Collagen XVIII α1 protein.

Endostatin inhibits the proliferation and migration of endothelial cells. It blocks apoptosis of cells and G1 to S phase transition in the cell cycle. It inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Mutations in this gene lead to Knobloch Syndrome (KS)a rare autosomal recessive disorder.