18706-33-7

Starting from 2-trifluoromethyl-4-hydroxy-6-chloroquinoline, chlorine atoms can be introduced at the 4- and 6-positions by a chlorinating agent (POCl₃ or SOCl₂) to obtain 4,6-Dichloro-2-(trifluoromethyl)quinoline. It can also be prepared by cyclizing aniline derivatives with trifluoroacetoacetate through the Conrad–Limpach reaction and then chlorinating.