1863905-38-7

PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

PF-06737007 is pan tropomyosin-related kinase (Trk) inhibitor.

TrkA: 7.7 nM (IC₅₀, in cell-based assays); TrkB: 15 nM (IC₅₀, in cell-based assays); TrkC: 3.9 nM (IC₅₀, in cell-based assays)

[1] Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. DOI:10.1021/acs.jmedchem.8b00633