182056-39-9

2-Bromo-4-iodoanisole is an electrophilic intermediate used in organic synthesis.

2-Bromo-4-iodoanisole is synthetically prepared by regioselective halogenations of 4-iodoanisole.

The general procedure for the synthesis of 2-bromo-4-iodo-1-methoxybenzene from 2-bromoanisole was as follows: to a stirred solution of 2-bromoanisole (1 mmol) in dichloromethane (CH2Cl2) or 1,2-dichloroethane ((CH2Cl)2) (0.1 M) was added sequentially Ph3PAuNTf2 (0.025 mmol, 19 mg; if using the 2:1 complex of Ph3PAuNTf2 with toluene) and N-iodosuccinimide (1.1 mmol, 248 mg). The reaction mixture was stirred at room temperature or reacted under reflux conditions until complete conversion of the feedstock was confirmed by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the solvent was evaporated under reduced pressure and the resulting crude product was purified by fast column chromatography using different gradient elutions of hexane and ethyl acetate (EtOAc) to give pure 2-bromo-4-iodo-1-methoxybenzene.

[1] Synlett, 2014, vol. 25, # 3, p. 399 - 402
[2] Synthetic Communications, 2007, vol. 37, # 8, p. 1259 - 1265
[3] Canadian Journal of Chemistry, 2005, vol. 83, # 10, p. 1808 - 1811
[4] Tetrahedron Letters, 2004, vol. 45, # 43, p. 8015 - 8018