ChemicalBook CAS DataBase List 18085-97-7

18085-97-7

Name	5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one
CAS	18085-97-7
Molecular Formula	C17H14O7
MDL Number	MFCD01081948
Molecular Weight	330.29
MOL File	18085-97-7.mol

Chemical Properties

Melting point	259-260 °C
Boiling point	619.0±55.0 °C(Predicted)
density	1.483±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Slightly)
form	Solid
pka	6.47±0.40(Predicted)
color	Pale Yellow to Light Yellow
Stability:	Hygroscopic
Major Application	food and beverages
InChI	InChI=1S/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3
InChIKey	GLAAQZFBFGEBPS-UHFFFAOYSA-N
SMILES	C1(C2=CC=C(O)C(OC)=C2)OC2=CC(O)=C(OC)C(O)=C2C(=O)C=1
LogP	1.300 (est)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Hazard Information

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from mugwort leaves, long-leaf Arnica montana flowers, aerial parts of Artemisia annua, stevia, Rehmannia root leaves, and aerial parts of Cistanche deserticola.

Uses

Jaceosidin exhibits anti-allergic, anti-inflammatory and apoptosis inducing activities.

Definition

ChEBI: A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apo tosis inducing activties.

in vivo

Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice^[3].
? Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice^[3].
? Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats^[3].

Animal Model:	5-week-old male BALB/c mice (23-26 g)^[3]
Dosage:	10 and 20 mg/kg
Administration:	P.O. once a day for 3 days
Result:	Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation.

Animal Model:	Male Sprague-Dawley rats (180-200 g)^[3]
Dosage:	20 mg/kg
Administration:	P.O., for 2 hour
Result:	Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively.

IC 50

Bax; COX-2

Spectrum Detail

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