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UNI418 is a dual inhibitor of PIKfyve and PIP5K1C with antiviral activity against SARS-CoV-2 (EC50=1.4 μM). UNI418 blocks ACE2-mediated SARS-CoV-2 viral endocytosis by inhibiting PIP5K1C (IC50=60.1 nM; Kd=61 nM). In addition, UNI418 inhibits the proteolytic activation of proteases regulated by PIKfyve (Kd=0.78 nM) to prevent SARS-CoV-2 from entering host cells[1].

[1] Seo, et al. "A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells." Experimental & Molecular Medicine (2024): 1-14. DOI:10.1038/s12276-024-01283-2