180083-49-2

SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis[1].

[1] Augustine‐Rauch K A, et al. Evidence for a molecular mechanism of teratogenicity of SB‐236057, a 5‐HT1B receptor inverse agonist that alters axial formation[J]. Birth Defects Research Part A: Clinical and Molecular Teratology, 2004, 70(10): 789-807. DOI:10.1002/bdra.20076