178600-20-9

Name	2,4,6-Octatrienoicacid, 7-[3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-, (2E,4E,6E)-
CAS	178600-20-9
Molecular Formula	C23H32O2
Molecular Weight	340.499
MOL File	178600-20-9.mol

Synonyms

LG1550 LG-1550 LGD-1550 ALRT-550 ALRT1550 ALRT-1550 ALRT 1550 2,4,6-Octatrienoicacid, 7-[3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-, (2E,4E,6E)-

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Hazard Information

Uses

ALRT1550 (LGD1550) is a selective retinoic acid receptor (RAR) agonist that binds RARs with exceptional potency, with Kd values of approximately 1-4 nM. ALRT1550 exhibits anti-proliferative activity, with an IC50 value of 0.22 nM in UMSCC-22B squamous carcinoma cells. In a mouse tumor xenograft model, ALRT1550 inhibited tumor growth in a dose-dependent manner, achieving a maximum inhibition rate of 89%. ALRT1550 is applicable for research in the field of cancer[1][2].

References

[1] Shalinsky DR, et al. A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice. Cancer Res. 1997 Jan 1;57(1):162-8. PMID:8988059
[2] Zhang L, et al. Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells. J Med Chem. 1996 Jul 5;39(14):2659-63. DOI:10.1021/jm960285j

Supplier

Suzhou Meishi Biotechnology Co., Ltd.

Telephone 1173954148q

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1822805/0_EN.htm

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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178600-20-9 1208-65-7

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