1785665-61-3

VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation[1].

CXCR7: 8.1 (pKi)

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[1] Wijtmans M, et al. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur J Med Chem. 2012 May;51:184-92. DOI:10.1016/j.ejmech.2012.02.041
[2] Nugraha AP, et al. C?X?C receptor 7 agonist acts as a C?X?C motif chemokine ligand 12 inhibitor to ameliorate osteoclastogenesis and bone resorption. Mol Med Rep. 2022 Mar;25(3):78. DOI:10.3892/mmr.2022.12594