ChemicalBook CAS DataBase List 1782573-78-7

1782573-78-7

Name	N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride
CAS	1782573-78-7
Molecular Formula	C19H16Cl2N4O2
Molecular Weight	403.26
MOL File	1782573-78-7.mol

Chemical Properties

storage temp.	4°C, away from moisture
solubility	DMSO : 16.67 mg/mL (37.91 mM; ultrasonic and warming and adjust pH to 8 with NaOH and heat to 80°C)
form	Solid
color	Off-white to light yellow

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Animal Model:	SCID mice implanted with human fetal bone chips and then INA6 cells are directly injected into mice^[1]
Dosage:	50 mg/kg
Administration:	Oral administration; twice daily; 3 weeks
Result:	Inhibited human multiple myeloma cell growth in vivo.

Animal Model:	Two-month-old female Lewis rats^[2]
Dosage:	30 mg/kg, 10 mg/kg, 3 mg/kg, or 1 mg/kg
Administration:	Oral administration; twice daily; 3 weeks
Result:	Protected against bone and cartilage destruction in a rat model.