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(E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe. (E)-2-Hexadecenal has been shown to induce cytoskeletal reorganization that results in cell rounding, detachment, activation of downstream JNK targets, and eventual apoptosis in various cell types. It reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.

(E)-2-Hexadecenal alkyne (compound 2) is a chemical probe used to explore the cellular targets of 2-trans-Hexadecenal. It can covalently modify multiple proteins in cells and provide a tool for studying lipid metabolism-related diseases.

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[1] Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2- trans-Hexadecenal