177404-21-6

Hazard Information

Questions And Answer

• Structure

  Leptin is produced as a 167-aa residue preprohormone, including an N-terminal 21-aa signal peptide, and is released as a 146-aa peptide after enzymatic cleavage.;

• Properties

  Human leptin: Mr 16,000, pI 5.8. Leptin is soluble in water.;

• Uses

  Leptin analogs are used for the treatment of lipodystrophy in clinical settings.;

• Gene, mRNA, and precursor

  The human leptin gene, LEP, location 7q31.3, consists of three exons. Human leptin mRNA has a 3.5kb length that encodes a signal peptide of 21 aa residues and a mature protein of 146 aa residues.;

• Regulation of synthesis and release

  The synthesis and release of leptin are regulated by environmental factors. In humans and rodents, obesity stimulates leptin synthesis and increases the plasma concentrations. Exercise decreases the plasma leptin concentrations in the rat. Exposure to low temperature suppresses leptin gene expression in WAT and reduces the plasma leptin concentrations in rodents. While fasting attenuates leptin gene expression, feeding restores the levels of gene expression.;

Supplier

Related Products