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P-TOLYL-BETA-D-GLUCURONIDE is a metabolite of o-Cresol (C781910), which is a compound used as a disinfectant and have also been used as antiseptic in surgery.

p-Cresol Glucuronide, is a metabolite of o-Cresol (C781910), which is a compound used as a disinfectant and have also been used as antiseptic in surgery.

P-TOLYL-BETA-D-GLUCURONIDE is a glucosiduronic acid that is beta-D-glucuronic acid in which the anomeric hydroxyl hydrogen is replaced by a p-tolyl group.

p-Cresol glucuronide is generated through a process called glucuronidationwhich is a phase II metabolism reaction in the liver. In this processp-cresola metabolite produced by the gut microbiota during the breakdown of dietary tyrosine and phenylalanineundergoes conjugation with glucuronic acid. This conjugation is catalyzed by the enzyme UDP-glucuronosyltransferase (UGT) to form p-cresol glucuronide. The resulting glucuronide metabolite is then excreted in the urine. This process plays a crucial role in the elimination of p-cresol from the body.

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