172820-23-4

Treatment of diabetic foot ulcer infections (antibacterial).

Cytolex (Abbott).

Pexiganan (MSI-78) is a 22-aa synthetic cationic antimicrobial peptide (AMP)an analog of magainin found in the African clawed frog (Xenopus laevis). Pexiganan is effective against both Gram-positive (staphylococci MIC ≤16 μg/mLstreptococci & methicillin-resistant S. aureus MIC 8-64 μg/mLS. pyrogenes MIC 16-256 μg/mL) and Gram-negative aerobes (MIC 4-32 μg/mLE. cloacae MCI 1-128 μg/mLA. faecalis 4-64 μg/mL) by disrupting bacteria cell wall or membrane.