1715025-34-5

Name	Benzamide, 4-[3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]-2-pyrazinyl]-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluoro-, hydrochloride (1:)
CAS	1715025-34-5
Molecular Formula	C26H28BrClF3N5O2
Molecular Weight	614.89
MOL File	1715025-34-5.mol

Synonyms

Rineterkib HCl Rineterkib hydrochloride Benzamide, 4-[3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]-2-pyrazinyl]-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluoro-, hydrochloride (1:)

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Chemical Properties

storage temp.	4°C, away from moisture and light
solubility	DMSO : 220 mg/mL (Need ultrasonic)
form	Solid
color	White to yellow

Hazard Information

Uses

Rineterkib hydrochloride (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF[1][2].

in vivo

ERK-IN-1 (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice^[1].

Animal Model:	Calu-6 NSCLC xenograft tumor models in mice^[1].
Dosage:	50, 75 mg/kg.
Administration:	Orally either daily (qd) or every other day (q2d) for 27 days.
Result:	Significantly reduced the tumor volume.

storage

4°C, away from moisture and light

References

[1] CAPONIGRO, et al. THERAPEUTIC COMBINATIONS COMPRISING A RAF INHIBITOR AND A ERK INHIBITOR. WO2018051306A1.
[2] Song Y, et al. Targeting RAS-RAF-MEK-ERK signaling pathway in human cancer: current status in clinical trials. Genes & Diseases, 2022.

Supplier

Shanghai Lollane Biological Technology Co.,Ltd.

Telephone021-52996696，15000506266 15000506266

Websitehttp://www.bioll.com

Chunchuang (Wuhan) Technology Co., Ltd

Telephone 15727060112

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1427518/0_EN.htm

Wuhan Shanhai Zhihe Biotechnology Co., Ltd.

Telephone 17771424646

Website

https://hanhongsci.com/

Telephone021-54306202 18917919676

Websitehttps://www.hanhongsci.com/

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.

Telephone025-66061636 19370895928

Websitehttps://www.aikonchem.com/

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