1708971-55-4

FGF401 is an inhibitor of FGF receptor 4 (FGFR4; IC₅₀ = 1.9 nM). It inhibits proliferation of Huh7 carcinoma cells with an IC₅₀ value of 12 nM. FGF401 induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids when administered at a dose of 45 mg/kg per day for four weeks. It also decreases serum cholesterol when administered at doses ranging from 5 to 45 mg/kg per day.

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