ChemicalBook CAS DataBase List 1453208-66-6

1453208-66-6

Name	ASP5878
CAS	1453208-66-6
Molecular Formula	C18H19F2N5O4
Molecular Weight	407.37
MOL File	1453208-66-6.mol

Chemical Properties

Boiling point	645.3±65.0 °C(Predicted)
density	1.41±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : ≥ 250 mg/mL (613.69 mM);Water : < 0.1 mg/mL (insoluble)
form	Solid
pka	14.41±0.10(Predicted)
color	Light yellow to yellow

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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Shanghai JiYi Biotechnology Co. Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Amadis Chemical Company Limited

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Wuxi Donghe Pharmaceutical Technology Co., Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Jingmo (Xiamen) Biotechnology Co., Ltd

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Shanghai hongqu biomedical technology co. LTD

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Shanghai Luofa Biochemical Technology Co., Ltd.

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Energy Chemical

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Shanghai Dexuan Pharmaceutical Technology Co., Ltd

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Jinan Jiuli Biotechnology Co. , Ltd.

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Nantong Hi-Future Biotechnology Co., Ltd

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Animal Model:	Four-week-old male nude mice (CAnN.Cg-Foxn1nu/CrlCrlj [nu/nu]) (Hep3B2.1-7 cells inoculated subcutaneously)^[1].
Dosage:	3 mg/kg.
Administration:	Orally once daily from days 14 to 52.
Result:	Induced tumor regression by 9% and 88% at 1 and 3 mg/kg, respectively, without affecting the body weight for 14 days. Induced the suppression of FGFR4 phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation.

Animal Model:	HCC orthotopic xenograft model (mouse)^[1].
Dosage:	3 mg/kg.
Administration:	Orally once daily for 24 days.
Result:	Exhibited a lower tumor burden than vehicle- and sorafenibtreated mice. Induced sustained tumor regression without tumor regrowth.

1453208-66-6

Chemical Properties

Hazard Information

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in vivo

IC 50

storage

Spectrum Detail

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