170488-57-0

Name	1H-Indole, 3-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-1-(phenylsulfonyl)- (9CI)
CAS	170488-57-0
Molecular Formula	C26H23NO6S
Molecular Weight	477.53
MOL File	170488-57-0.mol

Synonyms

Tubulin inhibitor 23 1H-Indole, 3-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-1-(phenylsulfonyl)- (9CI)

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Chemical Properties

Boiling point	701.4±70.0 °C(Predicted)
density	1.25±0.1 g/cm3(Predicted)

Hazard Information

Uses

Tubulin inhibitor 23 is a potent Tubulin inhibitor with an IC50 of 4.8 μM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia[1].

in vivo

Tubulin inhibitor 23 (2, 6 μM; add into embryo water) shows antiangiogenic activity in a dose-dependent manner^[1].
Tubulin inhibitor 23 (2, 6 μM; add into embryo water) suppresses the proliferation and metastasis of K562 cells in zebrafish xenografts in a dose-dependent manner^[1].

Animal Model:	3hpf zebrafish embryos^[1]
Dosage:	2.0, 6.0 μM
Administration:	Add into embryo water
Result:	Decreased the number and length of ISVs (intersegmental vessels) in a dose-dependent inhibition pattern.

Animal Model:	Transgenic zebrafish (fil1:EGFP) (K562 cell xenograft)^[1]
Dosage:	2, 6 μM
Administration:	Add into embryo water
Result:	Reduced intensities and decreased tumour area.

References

[1] Yao Y,wt al. Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):652-665. DOI:10.1080/14756366.2022.2032688

Supplier

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

Shandong Dayou Pharmaceutical Research and Development Co., Ltd.

Telephonedayouchem@126.com 15165037910

Website

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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