ChemicalBook CAS DataBase List 170355-78-9

170355-78-9

Name	4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid
CAS	170355-78-9
Molecular Formula	C31H34O5
MDL Number	MFCD13176719
Molecular Weight	486.6
MOL File	170355-78-9.mol

Chemical Properties

Boiling point	668.6±55.0 °C(Predicted)
density	1.227±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml
form	A crystalline solid
pka	4.13±0.10(Predicted)
color	White to off-white

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Animal Model:	Mice submitted to 10 months of ethanol consumption^[2].
Dosage:	0.6 mg/kg
Administration:	Subcutaneous injection; daily, for 22 days.
Result:	Decreased brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels.

Animal Model:	Male and female mice (3 weeks)^[3].
Dosage:	1.6 mg/kg
Administration:	Oral gavage/intragastric; daily, for 31 days.
Result:	Growth plate closure had largely been prevented in LDE225/antagonist co-treated mice compared with those receiving LDE225 only.

170355-78-9

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